Hyaluronic Acid, how does it work?


Hyaluronic Acid is naturally present in our body, generally found among the connective, epithelial and nerve tissues. It is located between the eyes, cartilages, around the joints and especially under the skin. 

It is a disaccharide (glycosaminoglycan) polymer of fairly large size (about that of a microbe), of carbohydrate nature with strong water retention powers. An essential component of the extracellular matrix, it is necessary for the proliferation and migration of cells. It has a gel appearance. Located in the dermis, it constitutes the ‘gel’, so to speak, in which the fibroblasts bathe. But its concentration decreases with age, by about 10% every ten years. Fortunately, laboratories now know how to produce it through biotechnology.

How does it work?

Hyaluronic Acid is a sponge that can retain up to 1000 times its weight in water. It thus brings volume and density to the dermis, and has a high moisturizing power. But its action depends above all on its mode of application and the quantity used.


Hyaluronic Acid is widely used in plastic surgery, by injection, in particular in smoothing out wrinkles. In injections, large molecules (1 million Daltons) cross the skin barrier through the needle and are sent into the dermis in the form of a replumping gel. The expertise of the doctor will make the difference as to the result. The effect lasts between 4 and 6 months for a price varying between 400 euros and 600 euros. The Hyaluronic Acid molecules are eliminated little by little through the blood and then the urine.


Do all creams have the same effect?

No, that would be too simple. Depending on the form of Hyaluronic Acid used, the penetration and action in the skin vary. Several categories of Hyaluronic Acid can be used. They are differentiated by their size:

A) Hyaluronic Acid, usually used in cosmetics, is the ‘largest’. But this molecule is too big to pass through the cornea (or stratum). It acts only as a ‘moisturizing coat’ that remains on the surface of the skin. The Grangettes Laboratories Geneva have not retained this molecule for their cosmetics because in order to pass through the skin barrier it needs, of course, to be injected by the doctor. ‘Moisturizing coat’ creams do not make it possible to work in depth. 

B) Fragmented Hyaluronic Acid (HAF). Rarer, fragmented, and combined with a ‘carrier’ stemming from the work of the CNRS (National Scientific Research Council), this is far more effective than the previous product, as it is smaller. It crosses the skin barrier and procures a deep moisturizing and revitalizing effect. This is what the Grangettes Laboratories Geneva use. As a cream, Fragmented Hyaluronic Acid is combined with water and its life cycle is also limited. It is eliminated little by little through the blood and then the urine. This type of Fragmented Hyaluronic Acid, rare and penetrating, is destined for high quality cosmetic products, for regular daily treatment.

C)  A revolution: Pure Anhydrous Fragmented Hyaluronic Acid, in other words without water (average molecular weight 500 000 Daltons). A world exclusivity from the Grangettes Laboratories Geneva, it revolutionises anti-wrinkle treatments because the molecules are even smaller and can work even deeper. It thus penetrates up to the epidermal junction (limit of the dermis) where it acts as a sponge, capturing the water of the cells for an immediate smoothing action. In depth it also enhances the fabrication by the fibroblasts of brand new endogenous Hyaluronic Acid, thus providing sustainable effect over time. Its elimination takes place through the normal ageing cycle of the cell.

This revolution is at the base of our intensive care product 

"Lifting without Surgery" which can be applied as an anti-ageing and anti-wrinkle cosmetic treatment, even alternating with other creams, as it is very effective.